Table 1 Significant TWAS genes for ADHD
TWAS identified gene | Tissue | Best eQTL | Direction, Z-score | TWAS P-value | Permutation P-value | Implicated in 2019 ADHD GWAS | Previously implicated GWAS loci | Previous GWAS implicated genes |
|---|---|---|---|---|---|---|---|---|
CCDC24 | Cerebellum | rs12741964 | −6.11 | 9.48E−10 | 0.02 | Yes | 1:44184192 | a |
ARTN | Putamen basal ganglia | rs2906457 | 5.68 | 1.31E−08 | 0.04 | Yes | 1:44184192 | a |
ARTN | Cerebellar hemisphere | rs223508 | 5.65 | 1.59E−08 | 0.06 | Yes | 1:44184192 | a |
ELOVL1 | DLPFC | rs1199039 | 5.64 | 1.62E−08 | 0.05 | No | 1:44184192 | a |
TIE1 | DLPFC | rs3768046 | 5.27 | 1.31E−07 | 0.18 | No | 1:44184192 | a |
MED8 | DLPFC | rs11210892 | −5.14 | 2.72E−07 | 0.06 | No | 1:44184192 | a |
MANBA | Cerebellar hemisphere | rs223508 | 5.19 | 2.04E−07 | 0.001 | No | 1:44184192 | a |
CTC-498M16.4 | Substantia nigra | rs10044618 | −5.42 | 5.91E−08 | 0.07 | No | 5:87854395 | b |
RNF219-AS1 | Frontal cortex BA9 | rs1410739 | 5.10 | 3.39E−07 | 0.0003 | No | – | – |
