Table 1 Hydroxylated FA Species Fold-Change Abundance Compared to WT 12D Glc + FA

From: TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

Hydroxylated species

WT 12D Glc + FA

Mut 6D Glc + FA

Mut 12D Glc + FA

KO 6D Glc + FA

C6:0

1

1.79

5.82*

2.85

C8:0

1

3.61**

9.28**

C10:0

1

2.36

4.49

1.8

C12:0

1

2.70**

5.17***

6.08***

C14:1

1

4.84*

16.52***

10.52***

C14:0

1

1.98

6.82

24.15***

C16:1

1

3.58

14.07

102.47***

C16:0

1

3.05

9.97

189.69***

C18:3

1

2.33

11.08*

55.36***

C18:2

1

3.72

10.14

446.42***

C18:1

1

5.37

14.32

449.16***

C18:0

1

3.01

7.63

209.22***

C20:1

1

1.62

3.98

96.82***

C20:0

1

1.37

6.35

149.29***

  1. One-way ANOVA, n= 2–6 biological samples. *p < 0.05, **p < 0.01 and ***p < 0.001