Fig. 1

Analysis of PSD-95 tandem PDZ domains as a target for specific binders. a Sequence alignment of the first two PDZ domains of the PSD-95 paralog family (Rattus norvegicus). The red asterisks indicate residues directly involved in the binding of partner proteins. b Surface representations of PSD-95 tandem PDZ domains (PDB ID 3GSL, domain 1 on the left and domain 2 on the right) with ligand modelled in (RTTPV aligned from PDB ID 3JXT, black sticks) and with non-identical residues coloured in shades of blue according to the other tandem it is compared to (SAP97, PSD-93 or SAP102). c Scheme summarizing the location of highly conserved and more diverging regions on the surface of PSD-95 tandem PDZ domains with respect to other family members