Fig. 2
From: DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data
Validation of DC3 in simulation and real data. a Performance of HiChIP deconvolution scRNA-seq and scATAC-seq for GM12878 and K562 simulation data under different drop out rates. As a comparison, the random deconvolution results are presented. Error bars represent standard deviation. b Performance of joint clustering for GM12878 and K562 simulation data under different drop out rates. Error bars represent standard deviation. c FACS plot shows that in RA-day 4, 15.7 ± 3.2% cells are double positive for population-2-markers EpCAM and CD38. d Performance of HiChIP deconvolution in RA-day 4 real data. The HiChIP profile measured from double positive cells (red triangle) is much closer to that inferred for subpopulation 2 (blue triangle) than to the HiChIP profiles inferred for the other subpopulation (blue circle and blue rhombus) or measured from the bulk sample (red circle). All HiChIP profiles are represented using n-dimensional vectors with each dimension indicates corresponding loop counts. Source data are provided as a Source Data file
