Fig. 3
From: DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data
Analysis of subpopulation-specific regulatory networks. a–c Scatter plots of TF expression level and motif enrichment scores in the three subpopulations in RA-day 4. Node color represents expression specificity. Horizontal and vertical black lines indicate threshold values of motif enrichment scores and TF expression level. Key TFs are represented by squares (see text for key TF definition). d Top 30 key TFs in each subpopulation. Ranking is based on the product of log2(FPKM), motif enrichment score and expression specificity. e–g Dense subnetworks of key TFs plus expressed RA receptors in subpopulations 1 to 3 (left to right). Cadet blue color nodes represent the core subnetwork, violet nodes represent the upstream subnetwork and pink nodes represent the downstream subnetwork. Only the top 30 key TFs are shown. Source data are provided as a Source Data file
