Table 1 Heritability estimates in subjects of European ancestry (EUA)

From: International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Sample

N

N

10% prev

30% prev

50% prev

Cases

Controls

h 2 SNP

95% CI

h 2 SNP

95% CI

h 2 SNP

95% CI

p-value

All

 PGC2

23,212

151,447

0.04

0.02–0.05

0.05

0.03–0.07

0.06

0.04–0.08

3.2 × 10−8

 PGC1.5

12,823

35,648

0.03

0.01–0.06

0.05

0.01–0.08

0.05

0.01–0.09

0.011

Men

 UKB

10,389

115,799

0.13

0.1-0.15

0.17

0.14–0.21

0.19

0.15–0.23

2.1 × 10−18

 PGC2

9908

75,605

0.01

−0.02 to 0.03

0.01

−0.03 to 0.05

0.01

−0.03 to 0.05

0.63

 PGC1.5

6364

23,905

0.01

−0.04 to 0.05

0.01

−0.05 to 0.07

0.01

−0.05 to 0.08

0.69

 UKB

3544

51,700

0.11

0.04–0.17

0.15

0.05–0.24

0.16

0.05–0.26

1.4 × 10−3

Women

 PGC2

12,973

73,627

0.07

0.05–0.09

0.10

0.07–0.13

0.11

0.07–0.14

8.0 × 10−11

 PGC1.5

6128

9528

0.15

0.08–0.22

0.21

0.11–0.31

0.23

0.12–0.33

2.7 × 10−5

 UKB

6845

64,099

0.14

0.1–0.18

0.19

0.13–0.25

0.21

0.14–0.27

2.0 × 10−10

  1. Estimates are calculated using LD-score regression (LDSC) at different population prevalences after trauma exposure for the combined PGC freeze 2 samples, and separately for PGC1.5 (without the UK biobank), the UK biobank, and for men and women. Number of SNPs ranges from 1,160,174 to 1,175,791
  2. P-value is testing if h2SNP is different from zero and applies to all prevalences
  3. PGC2 all European ancestry subjects of PGC freeze 2 (including the UK biobank), PGC1.5 European ancestry subjects in the PGC1.5 EUA (not including the UK Biobank subjects), UKB UK Biobank European subjects, h2SNP mean SNP-based heritability, 95% CI 95% confidence interval, prev prevalence
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