Fig. 4
From: 5-Fluorouracil treatment induces characteristic T>G mutations in human cancer
Comparison between the 5-FU signature and COSMIC Signature 17. a Heatmap showing the cosine similarity scores for the in vitro 5-FU mutation spectrum and the in vivo obtained 5-FU signature with the COSMIC signatures. Both patterns show a strong resemblance with COSMIC Signature 17. b Replication strand bias of C[N>N]T mutations in 5-FU pretreated colon and breast samples and not 5-FU pretreated esophagus samples. Relative levels of each base substitution type in the left (leading) and right (lagging) DNA strands are shown for each cohort. Asterisks indicate a significant difference (P < 0.05, two-sided Poisson test). c The eleven-base signature context of C[T>G]T mutations are presented as Logo plots. The mutated T is centered in each plot with fixed positions left (5’ direction) and right (3’ direction) from the mutation position
