Fig. 6
From: Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator
RINGS identifies increased growth variability in the inflamed gut and between gut niches. a RINGS was used to compare PAS715 growth between the dextran sulfate sodium (DSS) inflamed, or streptomycin treated, mouse gut. b Histograms of normalized bacterial phase counts in gavage (black and grey) and fecal samples extracted 15 h post gavage in streptomycin (green) and DSS (red) treated mice c Bacteria extracted from feces of DSS-treated mice (red) showed elevated RINGS variability compared to gavage (black) and streptomycin (green) treated mice. Graphs show angular deviation of each datapoint and mean. Arrows identify mice dissected and analyzed in e. d Quantification of LCN-2 in feces 15 h post gavage demonstrates elevated inflammation in DSS-treated mice. e Bacteria plated from the dissected mouse gut of streptomycin control (top; n = 1) and DSS-treated (bottom; n = 1) mice. Graphs show histograms of normalized bacterial phase counts from populations dissected from regions of the gut (various colors) and feces (brown) compared to the original gavage (black). Source data are provided as a Source Data file
