Fig. 8 | Nature Communications

Fig. 8

From: The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

Fig. 8

Graphical summary of findings. We find that in murine models of PDAC, R848 acts on both host and tumor to promote beneficial survival responses. In host, we observe decreased manifestations of cachexia by behavioral and molecular metrics. In tumor, we observe that dependent on whether epithelial cells recruit R848-sensitive stroma, TLR7 stimulation mediates anti-tumor responses including increased T-cell infiltration and cytotoxic activity. These factors converge to extend survival in orthotopic murine models of PDAC

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