Table 3 QRS variants with parent-of-origin effects

From: Sequence variants with large effects on cardiac electrophysiology and disease

Top QRS parameter

Variant

Chr.

Pos. (hg38)

EA/OA

EAF (%)

Locus

Pat. effect (s.d.)

Pat. P

Mat. effect (s.d.)

Mat. P

P het

R dur., V4

rs11761424

7

14,414,730

A/G

35

DGKB

0.068

6.5 × 10−15

0.018

0.034

4.1 × 10−5

R amp., V1

rs116904997

12

120,230,731

A/G

1.28

PXN

0.28

7.3 × 10−13

0.073

0.062

1.6 × 10−4

  1. We show results for Phet < 0.05/190 = 2.6 × 10−4. EA effect allele, OA other allele, EAF effect allele frequency, Pat. paternal, s.d. standard deviation, Mat. maternal, Phet P value for heterogeneity in the effect estimates between the paternal and maternal models, Dur. duration, Amp. amplitude
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