Fig. 3
From: Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
EnvSia156 homology and binding subsites. a Birdseye view of an EnvSia156 dimer with the van der Waals’ surface colored according to sequence conservation, calculated by aligning sequences (ClustalOmega) with the closest primary structure homologs found in GenBank using the BLASTP tool. The color pattern matches the alignment used to render the structure (Supplementary Fig. 3), with darker shades of green corresponding to full conservation and white to no conservation. b Detailed view of the catalytic site of EnvSia156 with putative substrate coordinating residues in a stick representation, colored according to sequence conservation. The −1 and putative +1 binding sub-sites are highlighted with dashed circles
