Fig. 2 | Nature Communications

Fig. 2

From: Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

Fig. 2

Genetic diversity patterns of the cis-regulatory region of CYP6P9b. a Maximum likelihood phylogenetic tree of CYP6P9a promoter haplotypes across Africa. b Neighbour-joining phylogenetic tree of CYP6P9b-based genetic distance between nine African populations (NST estimates). c Africa-wide TCS network for the CYP6P9b haplotypes showing predominant haplotypes in southern Africa. A fixed haplotype is observed in Benin (sky blue) and a nearly fixed haplotype is seen in Ghana (black). Other locations show a greater diversity. Lines connecting haplotypes and each node represent a single mutation event. d A maximum likelihood phylogenetic tree of CYP6P9b showing a cluster of highly diverse haplotypes before scale up of bed nets (pre-intervention) but a nearly fixed haplotype post-intervention. e TCS haplotype network in Mozambique pre- and post-intervention revealing a major resistant haplotype post-intervention but a more diverse set of haplotypes before pre-bed nets

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