Fig. 4

Geographical distribution of CYP6P9b Africa-wide. a Frequency of the CYP6P9B_R allele across Africa showing that it is highly predominant in southern Africa, moderately present in East Africa but completely absent elsewhere on the continent. b Map of Africa showing the distribution of the CYP6P9b-resistant alleles with a near fixation in southern Africa. The map was generated using a blank map freely available from https://www.rkkerkenschijndel.nl/map-of-africa-drawing.html and pie-charts representing frequency of both alleles in each location were added on the map. c Comparative distribution of the combined genotypes of CYP6P9a and CYP6P9b in Tanzania and RD Congo supporting an independent segregation of genotypes of both genes in the field. Source data are provided as a Source Data file