Fig. 6

CYP6P9b combines with CYP6P9a to further reduce bed nets’ efficacy. a Distribution of the combined genotypes of both CYP6P9a and CYP6P9b showing that genotypes at both genotypes combined to additively increase the ability to survive after exposure to PermaNet 2.0. b Ability to survive exposure to PermaNet 2.0 (Odds ratio) of the double homozygote-resistant (RR/RR) genotypes of CYP6P9a and CYP6P9b compared to other genotypes supporting the additive resistance effect of both genes. Significance is shown by ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, as estimated using Fisher’s exact test. c Ability to survive exposure to PermaNet 2.0 (odds ratio) of the combined homozygote resistant and heterozygote (RR/RS) genotypes of CYP6P9a and CYP6P9b compared to other genotypes. d Distribution of the combined genotypes of both CYP6P9a and CYP6P9b after exposure to PermaNet 3.0 revealing an additive effect of both genes in increasing the ability to blood feed. e Comparison of blood feeding ability of combined genotypes of CYP6P9a and CYP6P9b showing a significantly higher ability (odds ratio) to blood feed for mosquitoes that double homozygote resistant (RR/RR). Source data are provided as a Source Data file