Fig. 7
The hepatic mesothelium in development gives rise to a lineage of aHSCs that re-engages a mesothelial gene signature, and in adulthood is a limited de novo source of subcapsular WT1-defined aHSCs. a Only mesothelial-derived WT1-positive lineages of aHSCs re-engage a mesothelial gene signature after fibrotic injury. Data are represented as individual points with median (centre line), first and third quartiles (lower and upper box limits), 1.5x interquartile range (whiskers). b Lineage labelling of hepatic mesothelium was induced in adult WT1CreERT2/+;Ai14 animals before iterative injury with CCl4, and c livers stained for WT1 (green) and lineage-label (lilac). Scale bars 100 μm
