Fig. 8
Relative contributions of different mechanisms to dysfunction in the Fmr1-KO model. Model parameter space explored for 16 different possible combinations of simulated Fmr1+/Y (‘WT’) and Fmr1−/Y (KO) conditions (four parameter groups, two possible genotypes, i.e. 42 combinations). Spike firing conditions (in response to five repetitive stimuli) are shown in green for each intermediate rescue scenario as well as Fmr1−/Y to Fmr1+/Y models. For each partial rescue scenario (either with Fmr1+/Y or Fmr1−/Y values, shown in blue and red, respectively), the total count of spike firing conditions across the whole 5–50 Hz and 0 < G/A < 10 range is shown compared with that of the wild-type simulation (i.e. full Fmr1−/Y model fired > 1 spike(s) in 45% more simulated FFI strength/input frequency conditions compared with the Fmr1+/Y model)
