Fig. 2
From: Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
KP activation correlates with IDO1 and IFN-related cytokines. a Scatter plot showing mRNA expression of IDO1 in white blood cells from controls (D21) and individuals with T21. Statistical significance was calculated using DESeq2. mRNA expression values are displayed in reads per kilobase per million (RPKM). Bars represent median, 25th, and 75th percentile values. n = 19 independent samples 10 with T21. b Heat map showing significantly different cytokines identified in Mesoscale Discovery Assay in Cohort 3. Data from both the D21 and T21 samples were z-scored using the mean and SD from the D21 group. Significant differences were assessed using the Kolmogorov–Smirnov test and an FDR-adjusted p-value threshold of 0.05. c Scatter plots comparing kynurenine to tryptophan ratios to levels of the three most significantly correlated cytokines, IP-10, IL-10, and TNF-α. d Scatter plots comparing kynurenine to tryptophan ratios to levels of three significantly correlated interferons: IFN-γ, IFN-α2a, and IFN-λ (IL-29). Spearman’s rho (ρ) and FDR-corrected p-values are indicated for each pair. Panels b–d measured Cohort 3, n = 128 independent samples, 74 with T21 for panel b, n = 124 samples, 72 with T21 for panels c and d
