Fig. 4

Tryptophan catabolism is disrupted in the Dp16 model of DS. a Schematic of mouse models tested showing the localization key genes on chromosome 21, including four of the six IFN receptors in Dp16 mice (Ifnar1, Ifnar2, Ifngr2, and Il10rb). b Box and whisker plots showing the relative quantification in log₂ adjusted intensity of plasma kynurenine in the indicated mouse model. p-values were calculated using a two-tailed Student’s t-test (*p < 0.05). Boxplot shows median, 25th, and 75th percentile values. Error bars are 1.5 times the interquartile range (IQR) or the maximum data point if <1.5 IQR. N’s for each strain were WT−20, Dp10–15, Dp16–20, Dp17–19