Fig. 1
Association signals for systemic sclerosis in a large meta-GWAS. a Manhattan plot representing the meta-GWAS results. The −log10 of the p values are plotted against their physical chromosomal position. The red and blue lines represent the genome-wide level of significance (p < 5 × 10−8) and p value threshold at p < 1 × 10−5, respectively. The plot has been truncated at p < 1 × 10−30. The lowest p value was observed within the MHC region for rs6457617 (association test p = 3.25 × 10−43). b Locuszoom to depict independent association signals in IRF5-TNPO3. From left to right, locuszoom of the association signals in IRF5-TNPO3 for the global meta-analysis; association signals conditioned on the lead SNP (rs36073657), and conditioned on rs36073657 and the secondary signal at the locus (rs12155080)
