Table 1 Comparison of GZnP3 with previously published genetically encoded Zn²⁺ sensors

FRET

ZapCY1

2.5 pM^a

4.2

0

⁵

FRET

ZapCY2

811 pM ^a

1.4

0.33

⁵

FRET

ZapCmR1.1

n.d.

1.4

0.38

⁶¹

FRET

ZapCmR2

n.d.

1.2

0.33

⁶¹

FRET

ZapCV2

2.3 nM ^a

2.2

0.49

⁶²

FRET

ZapCV5

0.3 μM^a

1.5

0.36

⁶²

FRET

eCALWY-1

2 pM^b

1.6

−0.07^c

³

FRET

eCALWY-2

9 pM^b

1.6

0

³

FRET

eCALWY-3

45 pM^b

1.6

−0.14 ^c

³

FRET

eCALWY-4

630 pM ^b

1.7

−0.21 ^c

³

FRET

eCALWY-5

1.8 nM ^b

1.3

−0.27 ^c

³

FRET

eCALWY-6

2.9 nM ^b

1.3

−0.2 ^c

³

FRET

redCALWY-1

12.3 pM^b

1.2

0

⁶³

FRET

redCALWY-4

234 pM ^b

1.2

−0.15 ^c

⁶³

FRET

eZinCh-1

8.2 µM^b

n.d.

n.d.

^{3, 64}

FRET

eZinCh-2

1.0 nM ^b

2.6

0.65

^{27, 65}

Single FP

ZnGreen1

633 nM^a

2.5

0

⁶⁶

Single FP

ZnGreen2

20 μM^a

n.a

n.d

⁶⁶

Single FP

ZnRed

166 nM and 20 μM^a

n.a

n.d

^{28, 66}

Single FP

GZnP1

34 pM^a

2.2

0.46

²⁹

Single FP

GZnP2

352 pM ^a

4.5

2.5

²

Single FP

GZnP3

1.3 nM ^a

11

4