Fig. 4

EAE inhibition driven by DPR and DTR is independent of GCN2 and AHR. a Mean clinical EAE scores and cumulative scores (WT, +protein: n = 8; WT, −protein: n = 10; Gcn2^−/−,  +protein: n = 9; Gcn2^−/−, −protein: n = 10). b Mean clinical EAE scores and cumulative scores (WT, +trp: n = 10; WT, −trp: n = 10; Gcn2^−/− , +trp: n = 7; Gcn2^−/−, −trp: n = 10). c Mean clinical EAE scores and cumulative scores after 5-hydroxytryptophan (5-HTP) supplementation (+trp: n = 4; −trp: n = 6, −trp+ 5-HTP: n = 5). d Mean clinical EAE scores and cumulative scores of mice supplemented with indole-3-aldehyde (I3A) or indole-3-carbinole (I3C) (+trp: n = 3; −trp: n = 3; −trp +  I3A: n = 6; −trp + I3C: n = 6). e Mean clinical EAE scores and cumulative scores (WT, +trp: n = 5; WT, −trp: n = 5; Ahr^−/−,+trp: n = 5; Ahr^−/−, −trp: n = 5). f Mean clinical EAE scores and cumulative scores of germ-free (GF) mice (+trp: n = 8; −trp: n = 6). g T cell infiltration (n = 8 vs. n = 5), h macrophage infiltration (n = 5 vs. n = 6), i demyelination (n = 8 vs. n = 6) and j plasma trp levels (n = 8 vs. n = 6) of mice from f were determined at d16 post-immunization. Statistics: Mann–Whitney U-test for a–f; unpaired two-tailed Student’s t-test for g–j. Each dot represents one individual mouse. Data are presented as mean ± SEM. Source data are provided as a Source Data file