Fig. 7
From: A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
Comparison of Top2 activity in S. cerevisiae and human cells. Topological stress arising within chromosomes is primarily resolved by Top2 in IGRs in the compact S. cerevisiae genome. By contrast, in human cells, TOP2 activity is located around the binding sites of CTCF—a nuclear organising factor that both patterns cohesin dependent loop extrusion and causes local nucleosomal ordering—and also preferentially towards the 5′ end of genes, where it correlates with local transcriptional activity
