Fig. 5
From: Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease
Lower NCS-1 protein expression in human iPSC-derived dopaminergic neurons from Parkinson’s disease patients compared to controls. a Western blot analysis of Cav2.3 and NCS-1 (normalized to β-actin) protein levels in iPSC-derived SN dopaminergic-like neurons from control and GBA-1 Parkinson’s disease patients. b Cav2.3 and NCS-1 protein expression (relative to that of β-actin), as well as Cav2.3/NCS-1 ratios in iPSC-derived dopaminergic neurons derived from control (n = 8) and GBA-1 Parkinson’s disease (n = 10) samples. Data were generated from six differentiations in total with four different control lines and three different GBA-1 lines (see Supplementary Table 9A). Antibody specificities were confirmed on respective knockout mice. Error bars: SEM. Significances are indicated by asterisks: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. All data are detailed in Supplementary Table 9A/B and Supplementary Fig. 7. Source data are available as a Source Data file
