Fig. 10 | Nature Communications

Fig. 10

From: Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

Fig. 10

Structural and functional characteristics of the known conformations of the groove of Ca2+-bound nhTMEM16 scramblase. The groove conformations shown are (from left to right): Ca2+-bound closed (PDBID 6QMB18); intermediate (PDBID 6QMA18); ion-conductive (PDBID 6OY3, this study); membrane-exposed (PDBID 6QM918); and lipid-conductive (obtained from MD simulations21). In all structures, TMs 3–6 are colored in red, blue, white, and silver, respectively, and are labeled

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