Fig. 5 | Nature Communications

Fig. 5

From: An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Fig. 5

PPAA broadly enhances delivery of cationic biomacromolecules. a Structure of a vivo-morpholino constituted by phosphorodiamidite morpholino oligomer conjugated to a cationc octa-guanidine dendrimer. b Quantification and c representative confocal microscopy images of polymer dose-dependent CD47 vivo-morpholino uptake in human microvascular endothelial cells. d Quantification and e representative confocal microscopy images of vivo-morpholino (green) colocalization with the endolysosomal dye lysotracker (red). *p < 0.05, **p < 0.01, ***p < 0.001; one-way ANOVA followed by Tukey’s post hoc test. Data are presented as means ± SEM

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