Fig. 6
From: Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
Characterization of CMT2A-related mutants. a Overview of the CMT2A-mutation sites on MFN2. The CMT2A-related single-point mutation sites are specified as yellow spheres on MFN2IM structure colored as in Fig. 1b. b GTP turnover rates of selected CMT2A-related MFN2IM mutants in comparison with wild-type MFN2IM. Locations of these mutants are color-specified. c CMT2A-mutation sites on the putative G domain-HD1 contact of MFN2 in the transition state. The structural model of rearranged MFN2IM is generated base on the MFN1IM-\({\mathrm{GDP}} \bullet {\mathrm{BeF}}_{3}^{-}\) structure (PDB code 5YEW). CMT2A-related residues and their potential interaction partners are presented as ball-and-stick models. d Functional zones of MFN2 and the involved CMT2A-mutation sites. e Dimerization property of CMT2A-mutants on the putative G domain-HD1 interface in the presence of \({\mathrm{GDP}} \bullet {\mathrm{BeF}}_{3}^{-}\). Source data are provided as a Source Data file
