Fig. 5
From: Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors
Molecular interactions at the A11B8.2 TCR/CD1d–α-GlcADAG interface. a A11B8.2 TCR α-chain interactions with CD1d. b A11B8.2 TCR β-chain interactions with CD1d. c Superposition of NKT TCR–CD1d–microbial lipids ternary structures: CD1d–α-GlcADAG (wheat), CD1d–α-Gal-GSL (purple, PDB code: 3O8X), CD1d–α-GalCer (black, PDB code: 3HE6), CD1d–α-GlcDAG-s2 (light blue, PDB code: 3TA3), and CD1d–BbGL-2c (light green, 3O9W). d Superposition of CD1d–α-GlcADAG (wheat), CD1d–α-GalCer (black, PDB code: 3HE6), and CD1d–sulfatide (pale green, PDB code: 4EI5). CD1d is coloured in light grey. e CD1d interactions with α-GlcADAG headgroup. f A11B8.2 TCR interactions with α-GlcADAG. For clarity, only the hydrogen bonds are shown as red dashed lines and the α1- and α2-helices of CD1d are shown as cartoon representation and coloured in light grey. CDR loops are coloured as in Fig. 5. The framework residues are also coloured in green. CD1d is coloured in light grey
