Fig. 6
From: Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling
Neuronal network activity and NMDAR/AMPAR ratio in Ehmt1+/− mice. a Representative raster plot showing 2 min of recording of the activity exhibited by cultured primary neurons derived from Ehmt1+/+ and Ehmt1+/− mice grown on MEAs at DIV 20. Three network burst are highlighted for each raster. Graph showing the firing rate, network bursting rate and network burst duration of cultures from Ehmt1+/+ and Ehmt1+/− mice (gray and orange bar respectively) on MEA at DIV 28. n = 8 for Ehmt1+/+ and n = 6 for Ehmt1+/−. b NMDAR/AMPAR ratio and decay constant (i.e., Tau) in cortical slices (layer 2/3 auditory cortex) from Ehmt1+/+ and Ehmt1+/− mice at P21. n = 6 for Ehmt1+/+ and n = 8 for Ehmt1+/−. c Representative example traces of miniature excitatory postsynaptic currents (mEPSCs) excitatory events recorded from layer 2/3 from Ehmt1+/+ and Ehmt1+/− mice. Graph showing quantification of the frequency and amplitude of mEPSCs of Ehmt1+/+ and Ehmt1+/− mice. n = 8 for Ehmt1+/+ and n = 8 for Ehmt1+/−. Data represent means ± SEM. *P < 0.05, Mann–Whitney test was performed between two groups. Source data is available as a Source Data file
