Fig. 2: EphA3 hyperphosphorylation in Ift88-depleted β-cells.
From: Glucose homeostasis is regulated by pancreatic β-cell cilia via endosomal EphA-processing
a pEphA3 (Tyr779) and γ-tubulin protein levels in Tx- and veh-treated islets and quantification (n = 5, mean ± s.d.) b pEphA3 (Tyr779), EphA3, and EphrinB1 protein levels in shIft88 1 and 2 and scrambled RNA (control) and quantification. (n = 6, mean ± s.d.) c Phosphorylated p44/42 ERK/MAPK (Thr202/Tyr204) and ERK/MAPK protein levels (n = 4) in primary islets and MIN6m9 cells, pAkt (Ser437), Akt (n = 3), phosphorylated p85 (Tyr458) and p85 protein levels (n = 3) in MIN6m9 cells and quantification, mean ± s.d.
