Fig. 3

Foxp1 deletion elevates energy expenditure and resists to HFD-induced obesity. a, b VO₂ and VCO₂ of Foxp1^fl/fl and Foxp1_Ad^∆/∆ mice in metabolic cages at age of 3 months old. n = 7 biologically independent mice/each group. c, d Quantification of O₂ and CO₂ consumption in light and dark. e Dorsal view of Foxp1^fl/fl and Foxp1_Ad^∆/∆ mice after 8-week feeding with HFD at age of 6 months old. Bar, 2 cm. f Representative depot of BAT and sWAT in HFD-fed mice (e). Bar, 1 cm. g Body weight of HFD-fed mice. h Relative adiposity of HFD-fed mice. i Statistics of rectal temperature of HFD-fed mice. j, k GTT and ITT of HFD-fed mice. *P < 0.05; **P < 0.01; ***P < 0.001; n = 7 biologically independent mice/each group; error bar, mean ± SEM