Fig. 4
Survival and response of hypomethylating therapy for dominant and secondary mutations. a Kaplan–Meier curves for pairs of dominant and secondary mutations with significant effect. Representative four co-occurring pairs are shown in above the curves. Each graph depicts four different group results (both dominant and secondary mutation, only dominant mutations, only secondary mutations, and neither dominant nor secondary mutations). b, c Associations between the presence of mutations and responses for hypometylkationg therapy. Circle and whiskers indicate odds ratios (OR) and 95% confidence interval. Green circle depict responder (left panel) or complete response (CR) (right panel), whereas pink circle does nonresponders in both panels. Gray circle shows no significance. b Patients with TET2 or ASXL1 mutations. c Those with dominant or secondary mutations for TET2 or ASXL1 mutations.
