Table 1 Demographic data of 1809 MDS patients subject to sequencing.

From: Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes

Parameter

WES

TSa

Total cohort

Patient numbers

225

1584

1809

Median age

70.9

71.8

71.8

Ratio of male to female

1.2

1.7

1.6

Survival (median, months)

25

28

27

Diagnosis

 MDS

152 (68%)

1294 (82%)

1446 (80%)

 MDS/MPN

41 (18%)

171 (11%)

212 (12%)

 sAMLb

32 (14%)

119 (7%)

151 (8%)

Subtype of progression

 Low riskc

117 (52%)

926 (59%)

1043 (58%)

 High riskc

108 (48%)

658 (41%)

766 (42%)

  1. WES whole-exome sequencing, TS targeted sequencing, MDS myelodysplastic syndromes, MPN myeloproliferative neoplasms, sAML secondary acute myeloid leukemia from MDS or MDS/MPN
  2. aIn total, 36 common genes were sequenced in the entire cohort
  3. bAll sAML cases were determined derived from MDS (n = 137) or MDS/MPM (n = 14)
  4. cTwo groups based on IPSS-R scores (low risk as <=3.5 and high risk as >3.5) according to the transformation risk (Pfeilstöcker, M. et al.47)
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