Table 2 Significantly correlated pairs between dominant and secondary events.

From: Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes

Dominant

Secondary

Co-occurrence

Dominant only

Secondary only

Intact

OR

P-value

q-value

Co-occurrence (CO) vs. mutually exclusive (ME)

ASXL1

ASXL1

1

136

211

1461

0.1

6.14E-07

2.77E-05

ME

ASXL1

SRSF2

16

121

72

1600

2.9

6.20E-04

8.15E-03

CO

BCOR

ETV6

8

40

27

1734

12.8

1.85E-06

6.99E-05

CO

BCOR

RUNX1

10

38

99

1662

4.4

3.93E-04

5.72E-03

CO

BCOR

U2AF1

6

42

26

1735

9.5

1.36E-04

2.63E-03

CO

CBL

ASXL1

10

15

202

1582

5.2

2.64E-04

4.38E-03

CO

EZH2

ASXL1

25

38

187

1559

5.5

5.99E-09

4.73E-07

CO

EZH2

EZH2

8

55

43

1703

5.7

2.69E-04

4.39E-03

CO

EZH2

FLT3

5

58

13

1733

11.4

2.64E-04

4.38E-03

CO

EZH2

RUNX1

23

40

86

1660

11.1

1.15E-13

2.17E-11

CO

EZH2

STAG2

10

53

74

1672

4.3

4.61E-04

6.41E-03

CO

EZH2

TET2

22

41

236

1510

3.4

2.26E-05

5.38E-04

CO

IDH2

ASXL1

17

33

195

1564

4.1

2.26E-05

5.38E-04

CO

IDH2

SRSF2

16

34

72

1687

11.0

3.24E-10

3.41E-08

CO

IDH2

STAG2

11

39

73

1686

6.5

9.52E-06

2.65E-04

CO

IDH2

TET2

0

50

258

1501

Infinity

6.99E-04

8.70E-03

ME

RUNX1

ASXL1

22

51

190

1546

3.5

1.25E-05

3.20E-04

CO

RUNX1

BCOR

8

65

37

1699

5.6

3.09E-04

4.88E-03

CO

RUNX1

IDH2

8

65

15

1721

14.1

1.44E-06

5.93E-05

CO

RUNX1

STAG2

17

56

67

1669

7.5

9.50E-09

6.42E-07

CO

SF3B1

ASXL1

20

354

192

1243

0.4

5.26E-06

1.72E-04

ME

SF3B1

DNMT3A

23

351

35

1400

2.6

7.71E-04

9.35E-03

CO

SF3B1

JAK2

29

345

24

1411

4.9

3.05E-08

1.92E-06

CO

SF3B1

NRAS

1

373

46

1389

0.1

3.66E-04

5.52E-03

ME

SF3B1

SRSF2

3

371

85

1350

0.1

4.56E-06

1.54E-04

ME

SRSF2

ASXL1

48

114

164

1483

3.8

6.05E-11

7.15E-09

CO

SRSF2

CBL

14

148

47

1600

3.2

6.53E-04

8.41E-03

CO

SRSF2

SRSF2

0

162

88

1559

Infinity

3.73E-04

5.52E-03

ME

SRSF2

STAG2

21

141

63

1584

3.7

6.40E-06

1.95E-04

CO

SRSF2

TET2

44

118

214

1433

2.5

5.46E-06

1.72E-04

CO

STAG2

ASXL1

19

41

193

1556

3.7

2.33E-05

5.38E-04

CO

TET2

TET2

125

222

133

1329

5.6

1.00E-31

9.47E-29

CO

TET2

ZRSR2

26

321

23

1439

5.1

7.51E-08

4.44E-06

CO

TP53

ASXL1

2

107

210

1490

0.1

1.75E-04

3.18E-03

ME

TP53

TP53

19

90

17

1683

20.8

5.12E-15

1.21E-12

CO

U2AF1

ASXL1

32

75

180

1522

3.6

1.27E-07

7.06E-06

CO

ZRSR2

TET2

23

49

235

1502

3.0

8.69E-05

1.79E-03

CO

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