Table 3 Clinical and molecular chracteristics of patients with CH-related (R) vs. -unrelated (U) MDSs.

From: Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes

  

CH-R (n = 627)

CH-U (n = 373)

P-value

Age

Mean

72.4

67.5

<0.0001

 

>60 y (%)

564 (92%)

283 (77%)

2.4 × 10−10

Sex

Male (%)

400 (63%)

254 (68%)

0.18

Diagnosis

   

2.0 × 10−6

 

MDS

499 (80%)

264 (71%)

0.002

 

MDS/MPN

86 (14%)

46 (12%)

0.56

 

sAML

42 (7%)

63 (17%)

6.4 × 10−7

Risk classification

   

4.7 × 10−5

 

Low risk

362 (58%)

165 (44%)

 
 

High risk

265 (42%)

208 (56%)

 

Karyotypes

 

Normal

389 (62%)

186 (50%)

0.0002

 

Complex

43 (7%)

33 (9%)

0.27

 

−5/del(5q)

59 (9%)

38 (10%)

0.74

 

−7/del(7q)

44 (7%)

41 (11%)

0.034

Number of mutations

Mean

3.2

2.6

<0.0001

Other mutationsa

 

RUNX1

76 (12%)

60 (16%)

0.078

 

EZH2

53 (8%)

45 (12%)

0.064

 

ZRSR2

53 (8%)

55 (15%)

0.0022

 

STAG2

47 (7%)

60 (16%)

3.2 × 10−5

 

U2AF1

46 (7%)

81 (22%)

2.5 × 10−10

 

BCOR/L1

39 (6%)

60 (16%)

1.0 × 10−6

 

IDH1/2

37 (6%)

53 (14%)

1.0 × 10−5

  1. aFrequently mutated genes, except for the nine genes identified in CHIP
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