Fig. 7

FASN inhibition prevents the development of invasive ductal carcinoma. a Inhibitory effects of G28UCM on tumor growth in MMTV-PyMT animals. Presented data are the mean values ± SEM (n = 11 mice per group). ***P < 0.001; Student’s t test. b Kaplan–Meier survival curves of mice treated with either vehicle (n = 11 mice) or G28UCM agent (n = 11 mice). Survival was calculated from the time of treatment initiation. Survival is increased in G28UCM-treated mice from 40 to 49 days (log-rank P < 0.01). c Average animal weight during vehicle (n = 11 mice) or treatment (n = 11 mice). d Upper panels: FASN staining in vehicle- or G28UCM-treated breast tumors. Lower panels: collagen IV staining (basement marker) reveals that G28UCM-treated MMTV-PyMT animals develop only noninvasive ductal in situ carcinoma proliferations. Representative images were obtained for each treatment. Scale bar, 500 μm