Fig. 7
Compartment-localized isoforms in neurons. a Scatter plot compares the isoform abundance between somata (x-axis) and neuropil (y-axis) compartments. Significantly localized isoforms were marker with blue (somata) or orange (neuropil) colors and example isoforms were highlighted. b, c Examples of the compartment-localized isoforms. Tracks from top to bottom are: genomic coordinates, Illumina read coverage in two replicates of somata samples and two replicates of neuropil samples, our FLT isoforms, CAGE clusters, 3′seq clusters, and RefSeq isoforms. Compartment localized isoforms were indicated by arrows. The two genes are: b Tac3, a neuropeptide-encoding gene, and c Bin1, a gene expressed in many tissues and associated with the Alzheimer’s disease. d Boxplots compare the expression levels (log2 TPM) between neuropil and somata localized isoforms (p value = 0.09, Mann–Whitney U test). Box edges represent quartiles, whiskers represent extreme data points no more than 1.5 times the interquartile range. Source data for panels a and d are provided in a Source Data file
