Fig. 1
From: Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
Manhattan plots of association for a B-ALL, b high-hyperdiploid ALL and c ETV6-RUNX1-positive ALL. y-axis shows genome-wide P-values (two-sided, calculated using SNPTEST v2.5.2 assuming an additive model) of > 6 million successfully imputed autosomal SNPs in 5321 cases and 16,666 controls. The x-axis shows the chromosome number. The red horizontal line represents the genome-wide significance threshold of P = 5.0 × 10−8. New associations are labelled in red. Other risk loci were reported in previous GWAS using subsets of ALL cohorts included herein.
