Table 1 Summary of results for genome-wide significant childhood ALL risk loci.
From: Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
CHR | SNP (Subtype) | Locus (gene) | Position (BP) | Risk allele | RAF | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
2 | rs17481869(ETV6-RUNX1) | 2q22.3 | 146124454 | A | 0.08 | 1.74 (1.45–2.09) | 2.37 × 10−09 |
5 | *rs886285 (High-Hyperdiploidy) | 5q31.1 (C5orf56) | 131765206 | T | 0.34 | 1.29 (1.18–1.41) | 1.56 × 10−08 |
6 | *rs210143 (High-Hyperdiploidy) | 6p21.31 (BAK1) | 33546930 | C | 0.73 | 1.30 (1.19–1.43) | 2.21 × 10−08 |
7 | rs17133805 | 7p12.2 (IKZF1) | 50477514 | G | 0.32 | 1.65 (1.56–1.74) | 5.28 × 10−71 |
8 | rs75777619 | 8q24.21 | 130185176 | G | 0.12 | 1.26 (1.17–1.36) | 2.30 × 10−09 |
9 | *rs76925697 | 9q21.31 | 83747371 | A | 0.96 | 1.52 (1.31–1.76) | 2.11 × 10−08 |
9 | rs113650570 | 9p21.3 (CDKN2A) | 21976402 | A | 0.02 | 2.32 (2.03–2.65) | 8.06 × 10−35 |
10 | rs10821936 | 10q21.2 (ARID5B) | 63723577 | C | 0.33 | 1.80 (1.71–1.89) | 1.19 × 10−106 |
10 | rs3824662 | 10p14 (GATA3) | 8104208 | A | 0.19 | 1.29 (1.21–1.38) | 3.57 × 10−14 |
10 | rs2296624 | 10p12.2 (PIP4K2A) | 22856946 | C | 0.67 | 1.25 (1.18–1.32) | 2.79 × 10−15 |
10 | rs12779301 | 10q26.13 (LHPP) | 126292655 | C | 0.66 | 1.22 (1.15–1.29) | 5.72 × 10−13 |
12 | rs4762284 | 12q23.1 (ELK3) | 96612762 | T | 0.32 | 1.15 (1.12–1.19) | 3.75 × 10−07 |
14 | rs2239630 | 14q11.2 (CEBPE) | 23589349 | A | 0.45 | 1.28 (1.22–1.35) | 1.72 × 10−21 |
17 | *rs10853104 (ETV6-RUNX1) | 17q21.32 (IGF2BP1) | 47092076 | T | 0.47 | 1.33 (1.21–1.47) | 1.82 × 10−08 |
21 | rs9976326 (High-Hyperdiploidy) | 21q22.2 (ERG) | 39776485 | T | 0.25 | 1.33 (1.21–1.46) | 4.79 × 10−09 |
