Table 1 Overview of the distinctive characteristics for each cluster (A-H)
Number of patients (n; % of cohort) | Tumor mutational burden (CDS) | SNV/InDel ratio | Number of structural variants | Main structural variant category or differentiating category | Ploidy status | Main mutational signature | Top 3 cluster-specific aberrations (% of cluster) | ETS-fusions (n) | Chromothripsis (n) | Kataegis (n) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Cluster A | 13 (6.6) | 36,88 | 0,99 | 149 | None | 1,92 | MSI | MSH6 (69.2), JAK1 (69.2), CIC (58.3) | 3 | 1 | 6 |
Cluster B | 13 (6.6) | 2,44 | 7,07 | 669 | Tandem duplications (>100 kb) | 2,39 | N/A | CDK12 (84.6), FGF3 (69.2), FGF4 (69.2) | 2 | 0 | 1 |
Cluster C | 15 (7.6) | 3,00 | 6,73 | 237 | Tandem duplications (<100 kb) | 3,19 | N/A | None | 7 | 1 | 2 |
Cluster D | 22 (11.2) | 4,39 | 7,28 | 323 | Deletions (>100 kb) | 2,16 | BRCA | BRCA2 (68.2) | 7 | 5 | 5 |
Cluster E | 55 (27.9) | 2,12 | 7,13 | 178 | None | 3,24 | N/A | None | 25 | 8 | 13 |
Cluster F | 20 (10.2) | 2,51 | 6,15 | 400 | None | 3,35 | N/A | Chromothripsis (80,0) | 10 | 16 | 7 |
Cluster G | 34 (17.3) | 2,12 | 6,13 | 222 | None | 2,98 | N/A | None | 23 | 8 | 5 |
Cluster H | 25 (12.7) | 2,30 | 5,81 | 201 | Insertions | 1,97 | N/A | None | 16 | 7 | 3 |
