Fig. 7 | Nature Communications

Fig. 7

From: Polarisome scaffolder Spa2-mediated macromolecular condensation of Aip5 for actin polymerization

Fig. 7

Cellular behavior of a polarisome complex protein Aip5. Under physiological growth, Spa2 recruits Aip5 to non-membranous polarisome complex at the bud tip for actin cable assembly together with Formin Bni1. Under stress conditions, Aip5 concentrates into in vivo reversible condensates, which undergo reversible LLPS in the cytoplasm in a Spa2-dependent manner. The Aip5 condensates showed compromised biochemical activity in polymerizing actin during the stress response and but reversed for actin assembly upon stress restoration

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