Fig. 5
Fluctuations in cortico-BG network signals predict immediate gaze shifts toward or away from objects associated with resolving uncertainty. a Mean normalized activity before information is enhanced when gaze is on the stimulus (dark dots/lines) compared with off the stimulus (light dots/lines), especially for intermediate reward probabilities when reward is uncertain. Data are from information tasks (left) and standard uncertainty tasks (right). This analysis was performed on all neurons where there was trial-to-trial variance in gaze behavior before receipt of information for all of the CSs (information tasks n = 117: ACC n = 62, icbDS n = 24, Pal = 31; standard uncertainty tasks n = 130: ACC n = 53, icbDS n = 53, Pal = 24). Error bars are ± 1 SE; *, *** indicate p < 0.05, 0.001 (signed-rank test). b Time course of gaze distance to the center of the stimulus (black) on an example trial with the Noinfo 50% reward CS. Gray area indicates the window for gaze to be on the stimulus. Green and purple lines indicate gaze shifts on and off the stimulus. c Mean time course of gaze distance to the stimulus aligned on gaze shifts off and on the stimulus (purple, green) and on control non-shift events (light colors), excluding blinks. Both gaze shift and control events have similar gaze trajectories until the moment of the gaze shift. d Mean time course of gaze shift-related normalized activity aligned on gaze shifts on the stimulus (green) and off the stimulus (purple). This analysis was performed on all neurons where there was at least one gaze shift on the stimulus and one gaze shift off the stimulus, as well as their matched control non-shift events, in each of three conditions: 0% reward (left), uncertain reward (middle), and 100% reward (right) (n = 300: ACC n = 156, icbDS n = 78, Pal n = 66). Shaded areas are ± 1 SE. *, **, *** indicate p < 0.05, 0.01, 0.001 (signed-rank test) before, during, and after the gaze shift. Uncertainty-related activity was enhanced before gaze shifts on the stimulus and reduced before gaze shifts off the stimulus, but primarily when animals were anticipating information about uncertain reward
