Fig. 4
From: Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
BRAF-variant multiplicity regulates subclonal dynamics. a Schematic of a selective sweep. The subclone under selection is in red. Progression along the arrow represents evolving clonal architecture. The accumulation of the ith passenger alleles associated with the subclone during selection (or hitch-hikers) is shown. μ is the neutral mutation rate. There is decreased genetic diversity as a result of the yielding of tumor subclones to a single clonal cluster if there is a rapid or hard selective sweep. b Modeling of the frequency trajectory of a new adaptive and ith passenger mutation during a selective sweep. Sweep parameters are s = 2.0 (hard) or 1.1 (soft) and μ = 0.001. The linear associations between the BRAF-variant multiplicity and the median c CCF or d genetic diversity across cancer types are shown. The slopes are non-zero (P < 0.0001)
