Fig. 7
From: Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
Optimal therapeutic strategies for categories of hypermorphic BRAF variants in LUAD. a Cells were incubated with AZD6244 for 24 h and treated as control (0 Gy) or with radiation. Survival is measured by proliferation assay. Data points represent mean ± s.e.m. b Schematic depicting sequential treatment strategies for hyperactivating mutations in BRAF. NSG mice bearing LUAD PDX with V600E mutation in the flank were block randomized into one of five treatments arms as shown. Dabrafenib and trametinib were given together for 14 days. Radiation (X-ray) was delivered over three consecutive days to a total dose of 6 Gy. Sequential treatments were given at least 24 h after the completion of the first therapy. Data are expressed as the mean ± s.e.m; n = 5 independent animals for each arm. The P-value of the χ2-test between [A] and [B] was <0.001
