Fig. 5
Assimilation and prediction of a respiratory neuron. a Intracellular recording of a respiratory neuron acquired from a slice of the Bötzinger region of the rat brain stem (black line). The neuron was stimulated with a current waveform alternating hyperchaotic oscillations and current steps (blue line). The RN SSN model was used to assimilate the experimental membrane voltage over a 920-ms-long window (green trace) to estimate the optimum parameters. a–c The completed RN SSN model predicts the membrane voltage (red traces) in quantitative agreement with observations (black traces) for a very wide range of current waveforms. Detail of: d an action potential, e gate variables and f ion current dynamics.
