Fig. 1
From: A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome
Schematic illustration of the computational framework. Step 1 MetSyn-related genes are identified by combining GWAS results and literature findings followed by a filtering step based on gene-set enrichment analysis. Step 2 Tissue-specific networks are constructed by integrating transcriptional regulatory networks from23 and PPI networks from HIPPIE db25. Step 3 Drug information is retrieved from DrugBank29 and LINCS database11. Step 4a and b Tissue-specific MetSyn and drug modules are established using network analysis. Step 5 To measure drug effects, a proximity score between drug and MetSyn modules is computed on the basis of network distance and semantic similarity
