Table 1 List of the drugs identified as possible repurposing candidates
From: A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome
DrugBank ID | Drug Name | Action | Target | Score | Module | Network |
|---|---|---|---|---|---|---|
DB00210 | Adapalene | agonist | RARG | 1.6618 | 2 | Adipose |
DB00210 | Adapalene | agonist | RXRB | 1.6925 | 2 | Adipose |
DB00523 | Alitretinoin | agonist | RARG | 1.6661 | 2 | Adipose |
DB04209 | Dequalinium | antagonist, inhibitor | XIAP | 1.7909 | 1 | Adipose |
DB03756 | Doconexent | activator | RXRA | 1.7103 | 2 | Adipose |
DB03756 | Doconexent | activator | RXRB | 1.6660 | 2 | Adipose |
DB09053 | Ibrutinib | inhibitor | BTK | 1.6147 | 1 | Adipose |
DB12332 | Rucaparib | antagonist | PARP1 | 1.6678 | 2 | Adipose |
DB08877 | Ruxolitinib | inhibitor | JAK1 | 1.7721 | 1 | Adipose |
DB04942 | Tamibarotene | agonist | RARA | 1.7222 | 2 | Adipose |
DB00210 | Adapalene | agonist | RXRB | 1.6871 | 2 | Liver |
DB03756 | Doconexent | activator | RXRA | 1.7047 | 2 | Liver |
DB03756 | Doconexent | activator | RXRA | 1.4948 | 3 | Liver |
DB03756 | Doconexent | activator | RXRB | 1.6819 | 2 | Liver |
DB03756 | Doconexent | activator | RXRB | 1.5372 | 3 | Liver |
DB00530 | Erlotinib | agonist | NR1I2 | 1.6684 | 2 | Liver |
DB09079 | Nintedanib | inhibitor | FGFR3 | 1.4473 | 2 | Liver |
DB04942 | Tamibarotene | agonist | RARA | 1.6667 | 2 | Liver |
DB00210 | Adapalene | agonist | RXRB | 1.6759 | 2 | Muscle |
DB00210 | Adapalene | agonist | RARG | 1.6676 | 2 | Muscle |
DB08916 | Afatinib | inhibitor | ERBB2 | 1.6765 | 3 | Muscle |
DB00523 | Alitretinoin | agonist | RARG | 1.7756 | 1 | Muscle |
DB00523 | Alitretinoin | agonist | RARG | 1.6643 | 2 | Muscle |
DB00523 | Alitretinoin | agonist | RXRB | 1.6620 | 2 | Muscle |
DB00523 | Alitretinoin | agonist | RARA | 1.6810 | 2 | Muscle |
DB05015 | Belinostat | inhibitor | HDAC1 | 1.7540 | 1 | Muscle |
DB05015 | Belinostat | inhibitor | HDAC2 | 1.7615 | 1 | Muscle |
DB05015 | Belinostat | inhibitor | HDAC4 | 1.8027 | 1 | Muscle |
DB06616 | Bosutinib | inhibitor | ABL1 | 1.6090 | 3 | Muscle |
DB08865 | Crizotinib | inhibitor | MET | 1.7883 | 1 | Muscle |
DB03756 | Doconexent | activator | RXRA | 1.7134 | 2 | Muscle |
DB01259 | Lapatinib | antagonist | ERBB2 | 1.8184 | 1 | Muscle |
DB06603 | Panobinostat | inhibitor | HDAC3 | 1.6110 | 2 | Muscle |
DB08877 | Ruxolitinib | inhibitor | JAK1 | 1.6745 | 3 | Muscle |
DB08877 | Ruxolitinib | inhibitor | JAK2 | 1.7140 | 3 | Muscle |
DB04942 | Tamibarotene | agonist | RARA | 1.6708 | 2 | Muscle |
DB08895 | Tofacitinib | antagonist | JAK1 | 1.7100 | 3 | Muscle |
DB08895 | Tofacitinib | inhibitor | JAK2 | 1.6920 | 3 | Muscle |
