Table 4 Genetic associations with plasma proteins.
From: Profiling of the plasma proteome across different stages of human heart failure
Protein | Locus (p value) | Location | Effect | Gene expression |
|---|---|---|---|---|
Vascular messengers | ||||
Nt-proBNP | 1p36 (5 × 10−9)* | cis | 2% | NPPB (heart) |
Matrix remodeling | ||||
TSP2 | 6q27 (2 × 10−47) | cis | 13% | THBS2 (heart) |
Immune system | ||||
CXCL13 | — | — | — | — |
CRP | 1q23 (6 × 10−10) | cis | 2% | — |
IL-1R antagonist protein | 2q13 (9 × 10−17) | cis | 5% | IL1RN (multiple) |
IL-18 receptor 1 | 2q12 (9 × 10−135) | cis | 37% | IL18R1 (heart) |
Complement system | ||||
C5a | 9q33 (3 × 10−10) * 1q31 (2 × 10−10) | cis trans | 1% 3% | C5 (multiple) CFH (multiple) |
C9 | 5p13 (4 × 10−10) | cis | 5% | — |
Coagulation system | ||||
Protein C | 2q14 (2 × 10−19) 20q11 (2 × 10−57) | cis trans | 6% 15% | PROC (liver, atria) PROCR (multiple) |
tPA | 8p11 (1 × 10−7) * | cis | 1% | PLAT (multiple) |
Intracellular or membrane-bound | ||||
Gelsolin | 9q33 (2 × 10−9) * | cis | 1% | GSN (blood) |
Carbonic anhydrase 13 | 8q21 (2 × 10−19) | cis | 6% | CA13 (multiple) |
Contactin-1 | 12q12 (2 × 10−11) 16p13 (1 × 10−17) | cis trans | 3% 5% | CNTN1 (multiple) TMEM8A (multiple) |
DUSP3 | — | — | — | — |
PRKACA | — | — | — | — |
Netrin receptor UNC5D | 8p12 (1 × 10−6) * | cis | 1% | — |
