Table 3 XCI skew in LCLs in this study is representative of XCI in purified primary immune cells.

From: Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age

Cell types

Degree of skewing in Twin A

Degree of skewing in Twin B

Degree of skewing in Individual C

LCLs

0.45

0.45

0.1

Monocytes

0.43

0.42

0.05

B cells

0.4

0.42

NA

T-CD4+ cells

0.28

NA

0.05

T-CD8+ cells

0.44

0.3

0.06

NK cells

0.4

NA

0.01

  1. Degree of skewing of XCI in immune cell types purified from two monozygotic twins (Twin A and Twin B) exhibiting skewed XCI patterns in LCLs, and from one individual (Individual C) exhibiting random XCI pattern in LCLs. Degree of skewing ≥ 0.3 indicates skewed XCI patterns
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