Fig. 5
MYDGF patch mutations and MYDGF receptor epitope. a Distribution of all (black) and the functionally important mutated residues (green, purple and orange) on the MYDGF surface in side view. b Distribution of all (black) and the functionally important mutated residues (green, purple and orange) on the MYDGF surface in top view. c Variants Q67A_F97R_E98R (green), R99E_E100R_S101A (purple) and Y71A_Y73 (orange) are located on the top face of MYDGF on loops 5 and 7. Fab8 (blue and turquois) is recognizing the β-sandwich edge of MYDGF including the N-terminal residues 1–18. A circle with dashed line marks the area on MYDGF, which facilitates interaction to the unknown MYDGF receptor.
