Fig. 7
From: Identification of the periplasmic DNA receptor for natural transformation of Helicobacter pylori
Putative roles of ComH in the transport of tDNA through the bacterial envelope. a ComH binds to double-stranded DNA through its C-terminal domain (light blue) and allows the retention of the dsDNA into the cytoplasm as proposed for ComEA in V. cholerae5,6,7. b Through its N-terminal domain (dark blue) interaction with ComEC OB domain, ComH feeds the transforming DNA to the inner-membrane channel that mediates the translocation of the DNA into the cytoplasm as a ssDNA.
